Seems that opinnions vary about this question. Does silencers influence accuracy?

I have spent a lot of time developing loads for my 22-250 that will stay inside 5mm if I do my part. The question is whether ataching a silencer will influence the barrel harmonics to such a degree that I will have to do load development again? As I use the 22-250 for varmint control a bit of silence seems the way to go, but not at the cost of accuracy and load development.

Two gunsmith had two different opinions - what now?